My Skye buildby Ravebug
You're playing as an assassin. An assassin must be fast and kill quick.
The cards I've used are Healing Vapors IV, Cloak II, Dissipate II, Ninja II and Nimble Fingers II.
Healing Vapors IV - Skye only has 1800 HP, so in my opinion this card is a necessity
Dissipate II - When using the Smoke Bomb to heal, you'll also need a way to get away as quick as possible
Cloak II and Ninja II - You have to get behind the enemy lines fast
Nimble Fingers II - Just a personal preference
The items I usually start with are Cauterize/Wrecker depending on the enemy team. After that I invest in Morale Boost and Kill to Heal